Summary: In a groundbreaking study, researchers have linked rare "de novo" genetic mutations--copy number variants (CNVs)--to pediatric obsessive-compulsive disorder (OCD). Using whole exome sequencing on nearly 1,000 families, they found significantly more of these mutations in children with OCD than in healthy peers. The findings help explain why OCD may arise even without inherited genetic risk and suggest the disorder has deeper roots in spontaneous genetic changes. While not a cure, the dis...
Summary: In a groundbreaking study, researchers have linked rare "de novo" genetic mutations--copy number variants (CNVs)--to pediatric obsessive-compulsive disorder (OCD). Using whole exome sequencing on nearly 1,000 families, they found significantly more of these mutations in children with OCD than in healthy peers. The findings help explain why OCD may arise even without inherited genetic risk and suggest the disorder has deeper roots in spontaneous genetic changes. While not a cure, the dis...
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